一基本信息

姓名：周虚

职称：教授

博士生导师

所在部门：动物科学系

研究方向：动物生殖调控

电子邮件：[email protected]

二学习与工作经历

1.受教育经历

1990.09-1993.06北京农业大学动物遗传育种与繁殖农学博士

1985.09-1988.06解放军兽医大学动物生产农学硕士

1981.09-1985.06广西农学院畜牧学农学学士

2.工作经历

1988.07-1992.11解放军兽医大学助教

1992.12-1995.08解放军农牧大学讲师

1995.09-2001.08解放军军需大学副教授

1996.03-1996.06日本东京农工大学访问教授

1999.10-2000.10英国诺丁汉大学访问学者

2001.09-2004.08解放军军需大学教授

2010.10-2010.11美国莱克姆森大学高级研究学者

2004.09-至今六宝典资料畜牧兽医学院、六宝典资料教授

三主要教学工作（承担的本科生、研究生课程）

主讲本科生课程：《动物繁殖学》、《动物繁殖生物技术》、《专业英语》（动科、生技、动医）、《医学英语》

研究生课程：《动物繁殖学专论》、《动物生殖生理学》、《分子生殖内分泌学》（博士生）

四主要科研工作（包括科研项目）

主持国家自然科学基金面上项目4项，“973”、“863”、国家科技支撑计划、转基因重大专项、国家重点研发计划等各类国家级项目子课题8项，省部级课题10余项。近三年主要课题包括：

1.miRNAs介导的BDNF调节猪卵泡颗粒细胞增殖的机制，自然基金面上项目，2018.01-2021.12，60万元，主持

2.奶牛高效生产关键技术的研发及产业化应用，吉林省校共建项目，2017.09-2020.09，300万元，主持

3.有害气体对奶牛乳腺发育和泌乳能力的影响，国家重点研发项目，2016.09-2020.09，44万元，骨干

4.RBP-4对猪卵泡颗粒细胞增殖的影响及机理研究，自然基金面上项目，2014.01-2017.12，80万元

5.母猪卵泡囊肿诊断和治疗技术的研究及应用2013.09-2015.09，长春市重大农业项目，25万元，主持

6.生殖相关小型猪模型建立，国家973子课题，2011.09-2015.09，90万元

五科研成果（著作、专利、论文）

论文

1.Shuxiong Chen, Fengge Wang, Zhuo Liu, Yun Zhao, Yanwen Jiang, Lu Chen, Chunjin Li,Xu Zhou*. Brain-derived neurotrophic factor promotes proliferation and progesterone synthesis in bovine granulosa cells. Journal of cellular Physiology. 2018. DOI: 10.1002/jcp.27536.

2.Sun L, Chen L, Jiang Y, Zhao Y, Wang F, Zheng X, Li C, Xu Zhou*. Metabolomic profiling of ovary in mice treated with FSH using ultra performance liquid chromatography/mass spectrometry.Biosci Rep. 2018. pii: BSR20180965. doi: 10.1042/BSR20180965.

3.Deng L, Li C, Chen L, Liu Y, Hou R, Xu Zhou*. Research advances on embryonic diapause in mammals.Anim Reprod Sci. 2018. pii: S0378-4320(18)30611-0. doi: 10.1016/j.anireprosci.

4.Wang F, Chen S, Jiang Y, Zhao Y, Sun L, Zheng B, Chen L, Liu Z, Zheng X, Yi K, Li C, Xu Zhou*. Effects of ammonia on apoptosis and oxidative stress in bovine mammary epithelial cells.Mutagenesis. 2018 Sep 4. doi: 10.1093/mutage/gey023.

5.Liu Z, Sun Y, Jiang Y, Qian Y, Chen S, Gao S, Chen L, Li C, Xu Zhou*. Follicle-stimulating hormone (FSH) promotes retinol uptake and metabolism in the mouse ovary.Reprod Biol Endocrinol. 2018;16(1):52.

6.Jiang Y, Zhao Y, Chen S, Chen L, Li C, Xu Zhou*. Regulation by FSH of the dynamic expression of retinol-binding protein 4 in the mouse ovary.Reprod Biol Endocrinol. 2018;16(1):25.

7.Jiang Y, Chen L, Taylor RN, Li C, Xu Zhou*. Physiological and pathological implications of retinoid action in the endometrium.J Endocrinol. 2018;236(3):R169-R188.

8.Zhu X, Chen S, Jiang Y, Xu Y, Zhao Y, Chen L, Li C, Xu Zhou*. Analysis of miRNA expression profiles in melatonin-exposed GC-1 spg cell line.Gene. 2018;642:513-521.

9.Gao S, Li C, Xu Y, Chen S, Zhao Y, Chen L, Jiang Y, Liu Z, Fan R, Sun L, Wang F, Zhu X, Zhang J, Xu Zhou*. Differential expression of microRNAs in TM3 Leydig cells of mice treated with brain-derivedneurotrophic factor.Cell Biochem Funct. 2017;35(7):364-371.

10.Li C, Zhu X, Chen S, Chen L, Zhao Y, Jiang Y, Gao S, Wang F, Liu Z, Fan R, Sun L, Xu Zhou*. Melatonin promotes the proliferation of GC-1 spg cells by inducing metallothionein-2 expression through ERK1/2 signaling pathway activation.Oncotarget. 2017;8(39):65627-65641.

11.Li C, Gao S, Chen S, Chen L, Zhao Y, Jiang Y, Zheng X, Xu Zhou*. Differential expression of microRNAs in luteinising hormone-treated mouse TM3 Leydig cells.Andrologia. 2018 ;50(1).

12.Shan Gao, Chunjin Li, Lu Chen,Xu Zhou*, Actions and mechanisms of reactive oxygen species and antioxidative system in semen,Molecular & Cellular Toxicology, 2017, 13, 143–154.

13.Wang H, Chen L, Jiang Y, Gao S, Chen S, Zheng X, Liu Z, Zhao Y, Li H, Yu J, Wang F, Liu Y, Li C, Xu Zhou*. Association of gene polymorphisms of estrogen receptor, follicle-stimulating hormone β and leptin with follicular cysts in Large White sows,Theriogenology. 2017;103:143-148.

14.Jiang Y, Li C, Chen L, Wang F, Xu Zhou*. Potential role of retinoids in ovarian physiology and pathogenesis of polycystic ovary syndrome.Clin Chim Acta. 2017;469:87-93.

15.Jiang YW, Zhao Y, Chen SX, Chen L, Li CJ, Xu Zhou*. NGF promotes mitochondrial function by activating PGC-1α in TM4 Sertoli cells.Andrologia. 2018;50(1).

16.Li C, Chen L, Zhao Y, Chen S, Fu L, Jiang Y, Gao S, Liu Z, Wang F, Zhu X, Rao J, Zhang J, Xu Zhou*. Altered expression of miRNAs in the uterus from a letrozole-induced rat PCOS model.Gene. 2017;598:20-26.

17.Li C, Chen S, Li H, Chen L, Zhao Y, Jiang Y, Liu Z, Liu Y, Gao S, Wang F, Yu J, Wang H, Rao J, Xu Zhou*. MicroRNA-16 Modulates Melatonin-Induced Cell Growth in the Mouse-Derived SpermatogoniaCell Line GC-1 spg Cells by Targeting Ccnd1.Biol Reprod. 2016 ;95(3):57.

18.Li CJ, Wang D, Xu Zhou*. Sperm proteome and reproductive technologies in mammals.Anim Reprod Sci. 2016t;173:1-7.

19.Li CJ, Jiang YW, Chen SX, Li HJ, Chen L, Liu YT, Gao S, Zhao Y, Zhu XL, Wang HT, Wang FG, Zheng L, Xu Zhou*. 4-Methylcatechol inhibits cell growth and testosterone production in TM3 Leydig cells by reducing mitochondrial activity.Andrologia. 2017;49(1).

20. Chunjin Li, Chao Chen, Lu Chen, Shuxiong Chen, Hongjiao Li, Yun Zhao,Jiahui Rao,Xu Zhou*, BDNF-induced expansion of cumulus oocyte complexes in pigs was mediated by microRNA-205, Theriogenology, 2016, doi:10.1016/j.theriogenology.2016.01.004.

21.Chunqiang Wang, Chunjing Li, Hongjiao Li, Wei Ma, Shuxiong Chen, Yun Zhao, Jiahui Rao, Xu Zhou*, Downregulation of the expression of inhibin αsubunit and betaglycan in porcine cystic follicles. Journal of Veterinary Medical Science, 2015, 77(11): 1419-1425.

22. Chunjin Li,Xu Zhou*, Melatonin and male reproduction, Clinica Chemica Acta, 2015, 446(2015):175-180.

23.Wanhong Li, Lu Chen, Shuxiong Chen, Hongjiao Li, Zhuo Liu, Lina Sun, Yun Zhao, Lianwen Zheng, Chunjin Li, Xu Zhou*, Polymorphisms in inhibin α gene promoter associated with male infertility, GENE. 2015, 559(2): 172–176.

24. Chunjin Li, Wanhong Li, Shuxiong Chen, Zhichen Kang, Lina Sun, Hongjiao Li, Lu Chen, Jiahui Rao, Yun Zhao, Jiaxin Yu, Xu Zhou*,4-Methylcatechol-induced cell damage in TM4 Sertoli cells, Cell Biology International, 2015, 36(6): 770-774.

25. Wanhong Li, Lina Sun, Shuxiong Chen, Chen Lu, Zhuo Liu, Xiaofeng Hou, Chao Chen, Yamei Han, Chunqiang Wang,Chunjin Li*, Xu Zhou^*, Association of inhibin-α gene polymorphisms with follicular cysts in large white sows, Theriogenology, 2015,84(6): 839-845.

26.Chunjin Li, Yonghe Ma, Kangle Yi, Chunqiang Wang, Wanhong Li, Zhuo Liu, Lina Sun, Shuxiong Chen, Jiaxin Yu, Hongjiao Li, Lu Chen, Xu Zhou*, The interactions between nerve growth factor and gonadotrophins in bovine oviduct, Animal Reproduction Science, 2014, 149(3-4): 117-123.

27. Chunjin Li,Xu Zhou*, The potential roles of neurotrophins in male reproduction, Reproduction, 2013, 145(4): R89-R95.

28.Chunqiang Wang,Jin Zhang,Yongfeng Sun,Dong Wang, Chunjin Li,Wanhong Li,Chen Lu,Zhuo Liu,Wu H,Xiaofeng Hou, ChaoChen,Xu Zhou*, Detection of neurotrophin 4 (NT-4) in ejaculated bull spermatozoa and its effect on spermatozoa mitochondrial activity,Reproduction in Domestic Animals, 2013, 48(1): 131-136.

29.Chunjin Li, Chenjiao Li, Xiaoling Zhu, Chunqiang Wang, Zhuo Liu, Wanghong Li, Chen Lu,Xu Zhou*, The expression and putative role of brain-derived neurotrophic factor and its receptor in bovine sperm,Theriogenolog, 2012, 77(3): 636-643.

30. Chunjin Li,Xu Zhou*, Gene transcripts in spermatozoa: Markers of male infertility, Clinica Chemica Acta, 2012, 413(13-14): 1035-1038.

31.Yanling Sun, Jin Zhang, Zhiguang Ping, Chunqiang Wang, Yongfeng Sun, Lu Chen, Xiaoyan Li, Chenjiao Li, Xiaolin Zhu, Zhuo Liu, Wei Zhang,Xu Zhou*, Relationship between apoptosis and proliferation in granulosa and theca cells of cystic follicles in sows,Reprod Dom Anim, 2012, 47(4): 601-608.

32.Wei Zhang, Kangle Yi,Yan H,Xu Zhou*. Advances on in vitro production and cryopreservation of porcine embryos.Anim Reprod Sci, 2012, 132(3-4):115-122

33. Hongyan Liang, Lu Chen, Zhuo Liu,Xu Zhou*, Expressions of functional follicle-stimulating hormone receptor and luteinizing hormone/chorionic gonadotrophin receptor in oviduct and uterus in prepubertal gilts, Livestock Science, 2012, 148(1-2): 74-80.

34. WeiZhang, KangleYi, ChaoChen, XiaofengHou,Xu Zhou*, Application of antioxidants and centrifugation for cryopreservation of boar spermatozoa,Anim Reprod Sci, 2012, 132(3-4): 123-128.

35.Chunjin Li, Lianwen. Zheng, Yongfeng. Sun, Chunqiang Wang,Wanhong Li, Chen Lu,Xu Zhou*, No association between the G196A and C270T polymorphism of the brain-derived neurotrophic factor gene and male infertility,Russian Journal of Genetics, 2012, 48(3): 405-407.

36.Lina Tang, Lu Chen, Chunjin Li, Yongfeng Sun, Yanling Sun,Xu Zhou*, Differential neurotrophin-4 mRNA expression in reproductive organs of prepubertal gilts with different dietary energy level,Journal of Animal and Veterinary Advances, 2012, 11(4): 443-448.

37.Kangle Yi, Chunjin Li, Qili Qin, Lu Chen, Yanling Sun, Huahai Chen, Deshun Shi andXu Zhou*, cDNA cloning and expression of the bovine factor in the germline alpha (FIGLA) gene in oocytes and ovarian follicles.Journal of Animal and Veterinary Advances, 2012, 11(2): 260-270.

38.Yongfeng Sun, Jing Zhang, Chunjin Li, Dong Wang，Yonghe Ma, Yanling Sun, Zhuo Liu, Chunqiang Wang,Xu Zhou*, Interaction between Neurotrophin 4 and gonadotrophin in bovine oviducts,Theriogenology, 2012, 78(1): 39-48.

39. Lu Chen, Kangle Yi, Yongfeng Sun, Yanling Sun, Lina Tang,Xu Zhou*, Expression of BDNF mRNA in porcine reproductive tissues during follicular phase and luteal phase and oocytes in GV and in vitro matured MII stage, J of Anim and Vet Advan, 2011, 10(19): 2571-2574.

40. Yanlin Sun, Jin Zhang, Zhiguang Ping, Lina Fan, Chunqiang Wang, Wanhong Li, Chen Lu, Lianwen Zheng, Xu Zhou*, Expression of 3β-hydroxysteroiddehydrogenase (3β-HSD) in normal and cystic follicles in sows, African Journal of Biotechnology, 2011, 10(32): 6184-6189.

41.Chunjin Li, Lu Chen, Yongfeng Sun, Hongyan Liang, Kangle Yi, Yanling Sun, Yonghe Ma, Xiaoyan Li, Wei Wu,Xu Zhou*, Molecular cloning, polymorphism and tissue distribution of the MHC class IIB gene in the Chinese goose (Anser cygnoides), British Poultry Science, 2011, 52(3): 318-327.

42. Chunjin Li, Yongfeng Sun, Kangle Yi, Chengjiao Li, Xiaoling Zhu, Lu Chen,Xu Zhou*, Detection of the SRY transcript and protein in bovine ejaculated spermatozoa,Asian-Australian journal of animal science,2011, 24(10): 1358-1364.

43. Yongfeng Sun, Chunjin Li, Yanling Sun, Lu Chen, Zhuo Liu, Yonghe Ma, Chunqiang Wang, Wei Zhang,Xu Zhou*, Expression of neurotrophin 4 and its receptor tyrosine kinase B in reproductive tissues during the follicular and luteal phases in cows,Asian-Australian journal of animal science, 2011, 24(3): 336-343.

44. Lianwen Zheng, Chunjin Li, Yongfeng Sun, Zhuo Liu,Xu Zhou*, Expression of brain-derived neurotrophic factor in mature spermatozoa from fertile and infertile men,Clinica Chemica Acta,2011, 412(1-2): 44-47.

45. Yanling Sun, Zhiguang Ping, Chunjin Li, Yongfeng Sun, Kangle Yi, Lu Chen, Xiaoyan Li, Xinglong Wang,Xu Zhou*, Comparative Proteomic Analysis of Follicular Fluids from Normal and Cystic Follicles in Sows,Reproduction in Domestic Animals,2011, 46(5): 889-895.

46. Chunjin Li, Lianwen Zheng, Chunqiang Wang,Xu Zhou*, Absence of nerve growth factor and comparison of tyrosine Kinase receptor A levels in mature spermatozoa from oligoasthenozoospermic, asthenozoospermic and fertile men,Clinica Chemica Acta,2010, 411(19-20): 1482-1486.

47. Chunjin Li, Yongfeng Sun, Kangle Yi, Yonghe Ma,Yanling Sun, Wei Zhang,Xu Zhou*, Detection of nerve growth factor (NGF) and its specific receptor (TrkA) in ejaculated bovine sperm, and the effects of NGF on sperm function,Theriogenology, 2010, 74(9): 1615-1622.

48.Xu Zhou*, Li C, Yi K, Liang H, Chen L, Sun Y, Niu S, Wu W. Patterns of variation of the major histocompatibility complex class IIB loci in Chinese goose (Anser Cygnoides).Immunogenetics. 2009 ;61(6):443-50.

49.Yi KL, Xu Zhou*, Shi DS, Chen HH, Qin QL, Chen Y, Li CJ, Zhao ZH, Xing SY. The mRNA expression of brain-derived neurotrophic factor in oocytes and embryos and its effects on the development of early embryos in cattle.Animal. 2008;2(12):1786-94.

50.Zhou X, Dong W, Zhuang LZ. Changes in the serum concentrations of gonadotrophins and oestradiol in peripubertal Chinese Beijing Black gilts, Veterinary Research Communications, 1995;19(1): 95-99

专利

1.一种奶牛乳房炎检测试剂盒（201611009459.3）

2.INHA基因的单链核苷酸序列作为动物超数排卵分子标记的应用及检测方法（ZL201510102365.X）

3.SRY抗体的应用（ZL201110355017.7）

4.一种肉牛专用精饲料（ZL201010587080.7）

教材

1.动物繁殖学，2015，科学出版社，主编

2.畜牧兽医专业英语听力教程， 复旦大学出版社， 2009，主编

3.动物繁殖学， 2003，吉林人民出版社，主编

4.动物繁殖生物技术，中国农业出版社，2006，副主编

六奖励与荣誉

曾获吉林省优秀博士论文指导教师、吉林省杰出青年学者、长春市优秀科技工作者,六宝典资料国际学生优秀指导教师等荣誉。获省部级科技进步二等奖2项，三等奖2项。