一、基本信息
姓 名：李纯锦
职 称：教 授
所在部门：六宝典资料
研究方向：动物繁殖调控和动物繁殖新技术的开发及应用
办公电话：0431-87836556
电子邮件：[email protected]
二、学习与工作经历
1.受教育经历
2005.09-2010.07六宝典资料动物遗传育种与繁殖农学博士
2001.09-2005.07甘肃农业大学动物科学农学学士
2.工作经历
2017.09-至今六宝典资料教授
2012.12-2017.09六宝典资料副教授
2011.10-2012.04 Texas A&M University，USA博士后
2010.09-2011.06 Weizmann Institute if Science, Israel博士后
三、主要教学工作（承担的本科生、研究生课程）
主讲本科生课程：《动物繁殖学》、《动物繁殖生物技术》、《种畜繁殖管理》
研究生课程：《动物繁殖学专论》
四、主要科研工作（包括科研项目）
1.省部共建青稞和牦牛种质资源与遗传改良国家重点实验室开放课题，2021，主持
2.第五批国家万人计划青年拔尖项目，畜牧学，2020-2023，主持
3.NGF/TrkA通路对牛睾丸支持细胞增殖的调节机理，自然基金面上基金，2017-2020,主持
4.BDNF对睾丸间质细胞睾酮合成的影响及机理研究，自然基金青年基金，2014-2016, 主持
5.奶牛乳腺炎快速检测及预防关键技术的研发，吉林省重点攻关项目，2017-2019，主持
6.大熊猫胚胎延迟着床机理及妊娠特征性物质筛选，国家重点研发，2017-2020，主持
7.氧化应激对胚胎着床的影响机制，吉林省教育厅，2019-2021，主持
8.特色黑猪高效养殖，长春市科技局，2018-2020，主持
9.基于免疫调节的奶牛性别控制技术研究，吉林省科技厅，2016-2018，主持
10.通过调节氧化应激提高母猪胚胎发育和产仔数的技术研究，长春市科技局，2019-2019,主持
11.奶牛乳房炎致病菌检测技术的研发，一牧科技（北京）有限公司，2017-2018，主持
12.奶牛精液品质分子标记的筛选应用与精液保存技术开发，西藏畜牧兽医研究所，2015-2017,主持
13.不同添加剂对藏猪生长的影响，西藏畜牧兽医研究所，2016-2018,主持
14.卵母细胞成熟的调节机制，六宝典资料优秀青年精英阶段培养项目，2018-2020，主持
15.NGF/TrkA在牛睾丸支持细胞增殖中的作用研究，2014-2017，六宝典资料优秀青年重点阶段培养项目，主持
16.睾丸支持细胞增殖研究，六宝典资料优秀青年后备人才项目，2015.09-2017.09，主持
17.母猪卵泡囊肿检测技术研发，扬州市“绿扬金凤”项目，2014.09-2017.09,主持
18.六宝典资料人才引进启动项目，2013.01-2014.01，主持
五、科研成果（著作、专利、论文）
课题组紧密围绕畜牧产业中的关键问题“家畜繁殖障碍”，开展了一系列深入研究。以第一或通讯作者发表SCI论文55篇，其中JCR 2区以上43篇，获国家授权专利10项。同时，成果获吉林省优秀博士论文、吉林省自然科学学术成果二等奖、辽宁省畜牧科技贡献一等奖、吉林省大学生创新技术和产品设计专利挑战赛优秀指导教师、国际学术会议论文优秀墙报奖。开发的猪卵泡囊肿检测技术，在吉林、辽宁等省份进行了示范推广，取得了显著的社会经济效益。
代表论文
1. Chenfeng Yuan, Zheng Li, Yun Zhao, Xin Wang, Lu Chen , Zijiao Zhao, Maosheng Cao, Tong Chen, Tariq Iqbal, Boqi Zhang, Wenjing Fan, Yameng Wei, Chunjin Li*, Xu Zhou. Follicular fluid exosomes: Important modulator in proliferation and steroid synthesis of porcine granulosa cells. FASEB J, 2021, 35(5):e21610. doi: 10.1096/fj.202100030RR.
2. Meng Tian, Yuwen Huang, Xin Wang, Maosheng Cao, Zijiao Zhao, Tong Chen, Chenfeng Yuan, Nan Wang, Boqi Zhang, Chunjin Li*, Xu Zhou. Vaccaria segetalis: A Review of Ethnomedicinal, Phytochemical, Pharmacological, and Toxicological Findings. Front Chem. 2021,9:666280. doi: 10.3389/fchem.2021.666280.
3. Maosheng Cao, Qiaoge Niu, XinYu Xiang, Chenfeng Yuan, Tariq Iqbal, Yuwen Huang, Meng Tian, Zijiao Zhao, Chunjin Li*, Xu Zhou. Brain-Derived Neurotrophic Factor Regulates Ishikawa Cell Proliferation through the TrkB-ERK1/2 Signaling Pathway. Biomolecules. 2020,10(12):1645. doi: 10.3390/biom10121645.
4. Qiaoge Niu, Maosheng Cao, Chenfeng Yuan, Yuwen Huang, Zijiao Zhao, Boqi Zhang, Xin Wang, Yameng Wei, Wenjing Fan, Xu Zhou, Chunjin Li*. Effect of nerve growth factor on the proliferation in newborn bovine testicular Sertoli cells. Reproduction. 2020,160(3):405-415.
5. Maosheng Cao, Chunjin Li(co-first), Yuliang Liu, Kailai Cai, Lu Chen, Chenfeng Yuan, Zijiao Zhao, Boqi Zhang, Rong Hou, Xu Zhou. Assessing Urinary Metabolomics in Giant Pandas Using Chromatography/Mass Spectrometry: Pregnancy-Related Changes in the Metabolome. Front Endocrinol (Lausanne). 2020,11:215. doi: 10.3389/fendo.2020.00215.
6. Shan Gao, Shuxiong Chen, Lu Chen, Yun Zhao, Liting Sun, Maosheng Cao, Yuwen Huang, Qiaoge Niu, Fengge Wang, Chenfeng Yuan, Chunjin Li*, Xu Zhou. Brain-derived neurotrophic factor: A steroidogenic regulator of Leydig cells. J Cell Physiol. 2019,234(8):14058-14067.
7. Fengge Wang, Shuxiong Chen, Liang Deng, Lu Chen, Yuwen Huang, Meng Tian, Chunjin Li*, Xu Zhou. Protective Effects of Astragaloside IV against LPS-Induced Endometritis in Mice through Inhibiting Activation of the NF-κB, p38 and JNK Signaling Pathways. Molecules. 2019, 24(2):373. doi: 10.3390/molecules24020373.
8. Fengge Wang, Yun Zhao, Shuxiong Chen, Lu Chen, Liting Sun, Maosheng Cao, Chunjin Li*, Xu Zhou. Astragaloside IV Alleviates Ammonia-Induced Apoptosis and Oxidative Stress in Bovine Mammary Epithelial Cells. Int J Mol Sci. 2019,20(3):600. doi: 10.3390/ijms20030600.
9. Shuxiong chen, Fengge Wang, Zhuo Liu, Yun Zhao, Yanwen Jiang, Lu Chen, Chunjin Li*,Xu Zhou. Brain‐derived neurotrophic factor promotes proliferation and progesterone synthesis in bovine granulosa cells. Journal of cellular Physiology. 2018. DOI: 10.1002/jcp.27536.
10. Deng L, Chunjin Li (co-first), Chen L, Liu Y, Hou R, Xu Zhou. Research advances on embryonic diapause in mammals.Anim Reprod Sci. 2018. pii: S0378-4320(18)30611-0. doi: 10.1016/j.anireprosci.
11. Wang F, Chen S, Jiang Y, Zhao Y, Sun L, Zheng B, Chen L, Liu Z, Zheng X, Yi K, Chunjin Li*, Xu Zhou. Effects of ammonia on apoptosis and oxidative stress in bovine mammary epithelial cells.Mutagenesis. 2018. doi: 10.1093/mutage/gey023.
12. Liu Z, Sun Y, Jiang Y, Qian Y, Chen S, Gao S, Chen L, Chunjin Li*, Xu Zhou. Follicle-stimulating hormone (FSH) promotes retinol uptake and metabolism in the mouse ovary.Reprod Biol Endocrinol. 2018;16(1):52.
13. Jiang Y, Zhao Y, Chen S, Chen L, Chunjin Li*, Xu Zhou. Regulation by FSH of the dynamic expression of retinol-binding protein 4 in the mouse ovary.Reprod Biol Endocrinol. 2018;16(1):25.
14. Jiang Y, Chen L, Taylor RN, Chunjin Li*, Xu Zhou. Physiological and pathological implications of retinoid action in the endometrium.J Endocrinol. 2018;236(3):R169-R188.
15. Wang H, Chen L, Jiang Y, Gao S, Chen S, Zheng X, Liu Z, Zhao Y, Li H, Yu J, Wang F, Liu Y, Chunjin Li*, Xu Zhou. Association of gene polymorphisms of estrogen receptor, follicle-stimulating hormone β and leptin with follicular cysts in Large White sows,Theriogenology. 2017;103:143-148.
16. Chunjin Li, Chen L, Zhao Y, Chen S, Fu L, Jiang Y, Gao S, Liu Z, Wang F, Zhu X, Rao J, Zhang J, Xu Zhou. Altered expression of miRNAs in the uterus from a letrozole-induced rat PCOS model.Gene. 2017;598:20-26.
17. Chunjin Li, Chen S, Li H, Chen L, Zhao Y, Jiang Y, Liu Z, Liu Y, Gao S, Wang F, Yu J, Wang H, Rao J, Xu Zhou. MicroRNA-16 Modulates Melatonin-Induced Cell Growth in the Mouse-Derived Spermatogonia Cell Line GC-1 spg Cells by Targeting Ccnd1.Biol Reprod. 2016 ;95(3):57.
18. Chunjin Li, Wang D, Xu Zhou. Sperm proteome and reproductive technologies in mammals.Anim Reprod Sci. 2016t;173:1-7.
19. Chunjin Li, Chao Chen, Lu Chen, Shuxiong Chen, Hongjiao Li, Yun Zhao,Jiahui Rao,Xu Zhou, BDNF-induced expansion of cumulus oocyte complexes in pigs was mediated by microRNA-205, Theriogenology, 2016, doi:10.1016/j.theriogenology.2016.01.004.
20. Chunjin Li, Xu Zhou, Melatonin and male reproduction, Clinica Chemica Acta, 2015, 446(2015):175-180.
21. Wanhong Li, Lina Sun, Shuxiong Chen, Chen Lu, Zhuo Liu, Xiaofeng Hou, Chao Chen, Yamei Han, Chunqiang Wang,Chunjin Li*, Xu Zhou, Association of inhibin-α gene polymorphisms with follicular cysts in large white sows, Theriogenology, 2015,84(6): 839-845.
22. Chunjin Li, Yonghe Ma, Kangle Yi, Chunqiang Wang, Wanhong Li, Zhuo Liu, Lina Sun, Shuxiong Chen, Jiaxin Yu, Hongjiao Li, Lu Chen, Xu Zhou, The interactions between nerve growth factor and gonadotrophins in bovine oviduct, Animal Reproduction Science, 2014, 149(3-4): 117-123.
23. Chunjin Li, Xu Zhou, The potential roles of neurotrophins in male reproduction, Reproduction, 2013, 145(4): R89-R95.
24. Chunjin Li, Chenjiao Li, Xiaoling Zhu, Chunqiang Wang, Zhuo Liu, Wanghong Li, Chen Lu, Xu Zhou, The expression and putative role of brain-derived neurotrophic factor and its receptor in bovine sperm,Theriogenolog, 2012, 77(3): 636-643.
25. Chunjin Li, Xu Zhou, Gene transcripts in spermatozoa: Markers of male infertility, Clinica Chemica Acta, 2012, 413(13-14): 1035-1038.
26. Yongfeng Sun, Jing Zhang,Chunjin Li (co-first), Dong Wang，Yonghe Ma, Yanling Sun, Zhuo Liu, Chunqiang Wang, Xu Zhou*, Interaction between Neurotrophin 4 and gonadotrophin in bovine oviducts,Theriogenology, 2012, 78(1): 39-48.
27. Lianwen Zheng,Chunjin Li (co-first), Yongfeng Sun, Zhuo Liu, Xu Zhou*, Expression of brain-derived neurotrophic factor in mature spermatozoa from fertile and infertile men,Clinica Chemica Acta,2011, 412(1-2): 44-47.
28. Chunjin Li, Lianwen Zheng, Chunqiang Wang, Xu Zhou*, Absence of nerve growth factor and comparison of tyrosine Kinase receptor A levels in mature spermatozoa from oligoasthenozoospermic, asthenozoospermic and fertile men,Clinica Chemica Acta,2010, 411(19-20): 1482-1486.
29. Chunjin Li, Yongfeng Sun, Kangle Yi, Yonghe Ma,Yanling Sun, Wei Zhang, Xu Zhou, Detection of nerve growth factor (NGF) and its specific receptor (TrkA) in ejaculated bovine sperm, and the effects of NGF on sperm function,Theriogenology, 2010, 74(9): 1615-1622.
专利
1.一种奶牛乳房炎检测试剂盒（ZL201611009459.3）
2.INHA基因的单链核苷酸序列作为动物超数排卵分子标记的应用及检测方法（ZL201510102365.X）
3.SRY抗体的应用（ZL201110355017.7）
4.一种牛支原体检测试剂盒（ZL201720308374.9）
5. 一种核酸荧光检测设备（ZL 201821482967.8）
6. 一种牛支原体检测试剂盒(ZL 201720308374.9)
7. 一种用于禽畜规模养殖场净化饮用井水的曝气装置（ZL 202010281625.5）
8.畜禽用防污染的储水设备(ZL 202020522452.7)
9.RBP4基因的SNP位点的应用及其检测引物与试剂盒(ZL 201610322863.X)
10. TSG的用途(ZL201610326072.4)
教材和专著
1.动物繁殖学，2015，科学出版社，副主编
2.高级动物免疫学，2017，科学出版社，参编
3.中国奶牛场关键生产性能现状白皮书，2019，中国农业技术出版社，参编
六、奖励与荣誉
1.入选国家级青年人才项目
2.六宝典资料唐敖庆领军教授（2020）
3.吉林省大学生创新技术和产品设计专利挑战赛优秀指导教师（2018）
4.吉林省优秀博士论文获得者（2012）
5.第五届“六宝典资料师德先进个人”（2017）
6.吉林省自然科学学术二等奖（2013）
7.辽宁省畜牧业科技贡献一等奖（2017）
8.六宝典资料教学成果二等奖（2013）
