一基本信息

姓 名：徐媛媛

职 称：副教授

所在部门：生物技术系

研究方向：基因修饰动物

办公电话：0431-87836176

电子邮件：[email protected]

二学习与工作经历：

2003-2008年，六宝典资料药学院生物工程专业理学学士

2008-2010年，六宝典资料药学院生物医学工程专业医学硕士

2010-2016年，六宝典资料基础医学院生物化学与分子生物学专业理学博士

2016-至今，六宝典资料生物技术系讲师

三主要教学工作（承担的课程）

本科生课程：生物化学，生物制药与发酵工程综合实验

四主要科研工作（包括科研项目）及近三年科研成果

1.博士后面上项目二等资助，2018M631879，PAX4基因过表达模型兔的构建及糖尿病相关机制研究，5万元，主持

2.Yuanyuan Xu(#), Yong Wang(#), Yuning Song, Jichao Deng, Mao Chen, Hongsheng Ouyang, Liangxue Lai(*), Zhanjun Li(*). Generation and phenotype identification of PAX4 gene knockout rabbit by CRISPR/Cas9 system, G3, 2018.6.27.

3.Yuning Song(#), Yuanyuan Xu(#), Mingming Liang, Yuxin Zhang, Mao Chen, Jichao Deng; Zhanjun Li(*). CRISPR/Cas9-Mediated Mosaic Mutation of SRY Gene Induces Hermaphroditism in Rabbits, Bioscience Reports, 2018.3.21, 38(2).

4.Mao Chen(#), Bing Yao(#), Qiangbing Yang(#), Jichao Deng, Yuning Song, Tingting Sui, Lina Zhou,HaoBing Yao, Yuanyuan Xu, Hongsheng Ouyang, Daxin Pang, Zhanjun Li(*), Liangxue Lai(*). Truncated C-terminus of fibrillin-1 induces Marfanoid-progeroidlipodystrophy (MPL) syndrome in rabbit, Dis Model Mech, 2018.3.5,11(4).

5.Sui Tingting(#), Liu Di(#), Liu Tingjun, Deng Jichao, Chen Mao, Xu Yuanyuan, Song Yuning, Ouyang Hongsheng, Lai Liangxue(*), Li Zhanjun(*). LMNA-mutated Rabbits: A Model of Premature Aging Syndrome with Muscular Dystrophy and Dilated Cardiomyopathy, Aging and Disease, 2018.2.16, 9(6).

6.Huan Liu(#), Tingting Sui(#), Di Liu, Tingjun Liu, Mao Chen, Jichao Deng, Yuanyuan Xu(*), Zhanjun Li(*). Multiple homologous genes knockout (KO) by CRISPR/Cas9 system in rabbit, Gene, 2018.1.12, 647:261-267.

7.Yuanyuan Xu(#), Jialin Liu, Li Hua, Yue Xiao, Yaping Tian, Sheng Guo, Xiaoling Zhang, Chunyan He, Liying Wang(*), Yongli Yu(*). An immune regulatory CCT repeat containing oligodeoxynucleotide capable of causing hair loss in male mice, Human and Experimental Toxicology, 2016, 35 (11):1161-1172.