一、基本信息：

姓名：韩杨

职称：副教授

所在部门：六宝典资料

研究方向：表观遗传衰老

办公电话：18943452381

电子邮件：[email protected]

二、学习与工作经历

2006.09 - 2010.06 六宝典资料畜牧兽医学院，生物技术专业，理学学士学位

2011.09 - 2014.06 六宝典资料，生物化学与分子生物学，理学硕士学位

2016.10 - 2021.04 德国亚琛工业大学亥姆霍兹生物医学工程研究所，细胞生物医学，理学博士学位

2020.12 - 2022.12 六宝典资料，国际交流计划引进项目，博士后

2023.03 - 至今 六宝典资料，副教授

三、主要科研工作：

1. 国家自然科学基金青年基金项目，32200466，30万，主持

2. 国家重点研发计划，SQ2022YFAYFA1100001，400万，项目骨干

3. 德国国家研究基金会项目，WA1706/8-1，191万欧元，参与

4. 国家自然科学基金项目，31201080，24万，参与

四、科研成果

1. Han Y, Eipel M, Franzen J, et al. Epigenetic age-predictor for mice based on three CpG sites. eLife, 2018, 7: e37462.

2. Han Y, Franzen J, Stiehl T et al. New Targeted Approaches for Epigenetic Age Predictions. BMC Biology, 2020, 18(1):17

3. Brown A, Schuetz D, Han Y, et al. The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function. Haematologica, 2019: haematol. 2019.213009.

4. Florian MC, Leins H, Gobs M, Han Y, et al. Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice. Aging Cell, 2020,19(9), e13208.

5. Frobel J, Božić T, Lenz M, Uciechowski P, Han Y, et al. Leukocyte counts based on DNA methylation at individual cytosines. Clinical chemistry, 2018, 64(3): 566-575.

6. Koop BE, Mayer F, Gündüz T, Blum J, Becker J, Schaffrath J, Wagner W, Han Y et al. Postmortem age estimation via DNA methylation analysis in buccal swabs from corpses in different stages of decomposition - A “proof of principle” study. International Journal of Legal Medicine, 2020,1-7.

7. Koop BE, Reckert A, Becker J, Han Y, et al. Epigenetic clocks may come out of rhythm – Implications for the estimation of chronological age in forensic casework. International Journal of Legal Medicine, 2020,1-14.

8. Song Y, Liu Z, Han Y, et al. DNA methylation-mediated silencing of FLT1 in parthenogenetic porcine placentas. Placenta, 2017, 58: 86-89.

9. Han Y, Ouyang H, Che D, et al. Elevated expression of vascular endothelial growth factor (VEGF) 120 in parthenogenetic porcine placentas. Biotechnology letters, 2014, 36(5): 913-917.

10. Huang Y, Ouyang H, Xie W, Chen X, Yao C, Han Y, et al. Moderate expression of Wnt signaling genes is essential for porcine parthenogenetic embryo development. Cellular signalling, 2013, 25(4): 778-785.

11. Luo W, Li Z, Huang Y, Han Y, et al. Generation of AQP2-Cre transgenic mini-pigs specifically expressing Cre recombinase in kidney collecting duct cells. Transgenic research, 2014, 23(2): 365-375.

12. Huang Y, Xie W, Yao C, Han Y, et al. Pluripotent-related gene expression analyses in single porcine recloned embryo. Biotechnology letters, 2014, 36(6): 1161-1169.

13. Zhang X, Wang D, Han Y, et al. Altered imprinted gene expression and methylation patterns in mid-gestation aborted cloned porcine fetuses and placentas. Journal of assisted reproduction and genetics, 2014, 31(11): 1511-1517.