一、基本信息

姓名：陈佳欢

职称：助理研究员

所在部门：六宝典资料

研究方向：动物疾病模型制备及机制研究

办公电话：13654302790

电子邮件：[email protected]

二、学习与工作经历

2012.09 - 2016.06 六宝典资料 生物技术（动物） 理学学士

2016.09 - 2021.06 六宝典资料 生物化学与分子生物学 理学博士

2021.09 - 2022.07 六宝典资料动物医学学院 项目资助博士后

2022.07 - 至今 六宝典资料 鼎新学者

三、主要科研工作（包括科研项目）

1. 博士后面上资助项目，2022M711305，8万元，2022.07 - 2023.07，项目负责人；

2. 纵向科研项目，猪发育及代谢相关突变品系创制，2021YFA0805901-1，90万，2021.12 - 2026.11，项目负责人；

3. 国家自然科学基金面上项目，高表达脂蛋白相关磷脂酶A2对猪血液中脂质水平的影响及机制研究，64万，2016.01 - 2019.12，参与； 

4. 科研成果（著作、专利、论文）

5. Chen J^#, Zhang H^#, Li L^#, Zhang X, Zhao D, Wang L, Wang J, Yang P, Sun H, Liu K, Chen W, Li L, Lin F, Li Z, Chen YE, Zhang J, Pang D, Ouyang H, He Y, Fan J, Tang X. Lp-PLA2 (Lipoprotein-Associated Phospholipase A2) Deficiency Lowers Cholesterol Levels and Protects Against Atherosclerosis in Rabbits. Arterioscler Thromb Vasc Biol. 2023 Jan;43(1):e11-e28. 

6. Chen J^#, An B^#, Yu B, Peng X, Yuan H, Yang Q, Chen X, Yu T, Wang L, Zhang X, Wang H, Zou X, Pang D, Ouyang H, Tang X. CRISPR/Cas9-mediated knockin of human factor IX into swine factor IX locus effectively alleviates bleeding in hemophilia B pigs. Haematologica. 2021 Mar 1;106(3):829-837. 

7. Wang J^#, Chen J^#, Li L, Zhang H, Pang D, Ouyang H, Jin X, Tang X. Clostridium butyricum and Bifidobacterium pseudolongum Attenuate the Development of Cardiac Fibrosis in Mice. Microbiol Spectr. 2022 Dec 21;10(6):e0252422.  

8. Shi Q^#, Chen J^#, Zou X, Tang X. Intracellular Cholesterol Synthesis and Transport. Front Cell Dev Biol. 2022;10:819281. 

9. Yu B, Zhang M, Chen J, Wang L, Peng X, Zhang X, Wang H, Wang A, Zhao D, Pang D, OuYang H, Tang X. Abnormality of hepatic triglyceride metabolism in ApcMin/+ mice with colon cancer cachexia. Life Sci. 2019 Jun 15;227:201-211. 

10. Zou X, Yang Y, Lin F, Chen J, Zhang H, Li L, Ouyang H, Pang D, Ren L, Tang X. Lactate facilitates classical swine fever virus replication by enhancing cholesterol biosynthesis. iScience. 2022 Nov 18;25(11):105353. 

11. Zou X, Lin F, Yang Y, Chen J, Zhang H, Li L, Ouyang H, Pang D, Tang X. Cholesterol Biosynthesis Modulates CSFV Replication. Viruses. 2022 Jun 30;14(7). 

12. Lin F, Zhang H, Li L, Yang Y, Zou X, Chen J, Tang X. PEDV: Insights and Advances into Types, Function, Structure, and Receptor Recognition. Viruses. 2022 Aug 9;14(8). 

13. Sun S, Zhang M, Yang Q, Shen Z, Chen J, Yu B, Wang H, Qu J, Pang D, Ren W, Ouyang H, Tang X. Resveratrol suppresses lipoprotein-associated phospholipase A2 expression by reducing oxidative stress in macrophages and animal models. Mol Nutr Food Res. 2017 Oct;61(10).  

14. Yang Q, Yuan H, Chen M, Qu J, Wang H, Yu B, Chen J, Sun S, Tang X, Ren W. Metformin ameliorates the progression of atherosclerosis via suppressing macrophage infiltration and inflammatory responses in rabbits. Life Sci. 2018 Apr 1;198:56-64. 

15. Yu B, Peng XH, Wang LY, Wang AB, Su YY, Chen JH, Zhang XW, Zhao DZ, Wang H, Pang DX, Ouyang HS, Tang XC, Zhang MJ. Abnormality of intestinal cholesterol absorption in ApcMin/+ mice with colon cancer cachexia. Int J Clin Exp Pathol. 2019;12(3):759-767.