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谢子聪

发布日期:2019-09-02 作者: 点击:

一、基本信息

:谢子聪

:副教授

电子邮件[email protected]

研究方向:基因表达与调控、抗病动物模型的开发、病毒与宿主分子作用机理

二、主讲课程

本科生:《基因工程》《生物制药与发酵工程综合实验》

研究生:《分子遗传学》

三、教育经历

2007.9-2011.6,六宝典资料,生物技术,大学本科

2013.9-2018.6,六宝典资料,生物化学与分子生物学,博士学位

四、工作经历

2019.1-2020.12,六宝典资料师资博士后

2020.12-2021.12,六宝典资料讲师

2021.12-至今,六宝典资料副教授

五、科研项目

1. 国家自然基金面上项目,3237296250万,主持;

2. 农业生物育种重大项目,2023ZD04043040392万,主持;

3. 国家自然科学基金青年基金项目,3190222925万,主持;

4. 国家重点研发计划,2019YFA0110702-0190万,主持

5. 中国博士后科学基金面上项目,2254928万,主持;

6. 重庆市自然基金面上项目,CSTB2022NSCQ-MSX048610万,主持;

7. 吉林省教育厅项目,JJKH20221040KJ2.5万,主持。

六、代表论文

1. Zicong Xie; Daxin Pang; Hongming Yuan; Huping Jiao; Chao Lu; Kankan Wang; Qiangbing Yang; Mengjing Li; Xue Chen; Tingting Yu; Xinrong Chen; Zhen Dai; Yani Peng; Xiaochun Tang; Zhanjun Li; Tiedong Wang; Huancheng Guo; Li Li;Changchun Tu;Liangxue Lai; Hongsheng Ouyang , Genetically modified pigs are protected from classical swine fever virus, PLOS Pathogens, 2018, 14(12):e1007193.

2. Zicong, Xie; Huping, Jiao; Haonan, Xiao; Yuan, Jiang; Zhenying, Liu; Chunyun, Qi; Dehua, Zhao; Shuyu, Jiao; Tingting, Yu; Xiaochun, Tang; Daxin, Pang; Hongsheng, Ouyang ; Generation of pRSAD2 gene knock-in pig via CRISPR/Cas9 technology, ANTIVIRAL RESEARCH, 2020, 174.

3. Chunyun Qi; Daxin Pang; Kang Yang; Shuyu Jiao; Heyong Wu; Chuheng Zhao; Lanxin Hu; Feng Li; Jian Zhou; Lin Yang; Dongmei Lv; Xiaochun Tang; Hongsheng Ouyang; Zicong Xie*; Generation of PCBP1-deficient pigs using CRISPR/Cas9-mediated gene editing, iScience, 2022,25(10).

4. Zicong, Xie; Ruize, Sun; Chunyun, Qi; Shuyu, Jiao; Yuan, Jiang; Zhenying, Liu; Dehua, Zhao; Ruonan, Liu; Qirong, Li; Kang, Yang; Lanxin, Hu; Xinping, Wang; Xiaochun, Tang; Hongsheng, Ouyang; Daxin, Pang ; Generation of a pHSPA6 gene-based multifunctional live cell sensor, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2021, 1868(2).

5. Zicong Xie; Daxin Pang; Kankan Wang; Mengjing Li; Nannan Guo;Hongming Yuan; Jianing Li; Xiaodong Zou; Huping Jiao; Hongsheng Ouyang; Zhanjun Li; Xiaochun Tang , Optimization of a CRISPR/Cas9-mediated Knock-in Strategy at the Porcine Rosa26 Locus in Porcine Foetal Fibroblasts, SCIENTIFIC REPORTS,2017, 7(3036).

6. Chao Lu; Daxin Pang; Mengjing Li; Hongming Yuan; Tingting Yu; Peixuan Huang; Jianing Li; Xue Chen; Huping Jiao; Zicong Xie*; Hongsheng Ouyang*, CRISPR/Cas9-Mediated Hitchhike Expression of Functional shRNAs at the Porcine miR-17-92 Cluster, Cells, 2019, 8(2).

7. Shuyu Jiao#, Chunyan Bai#, Chunyun Qi, Heyong Wu, Lanxin Hu, Feng Li, Kang Yang, Chuheng Zhao, Hongsheng Ouyang, Daxin Pang, Xiaochun Tang* and Zicong Xie*. Identification and Functional Analysis of the Regulatory Elements in the pHSPA6 Promoter. Genes 2022, 13 (2), 189.

8. Zhenying Liu#, Mingjun Zhang#, Peixuan Huang, Zhaoyang Ji, Chunyun Qi, Shuyu Jiao, Dehua Zhao, Yuan Jiang, Xue Chen, Dongmei Lv, Daxin Pang, Xin Zhang, Li Feng, Zicong Xie*, Hongsheng Ouyang*. Generation of APN-chimeric gene-edited pigs by CRISPR/Cas9-mediated knock-in strategy, Gene, 851, 2023, 147007, ISSN 0378-1119.

七、授权专利

1. 能有效编辑猪ROSA26基因的sgRNA及其应用;

2. 一种动物转基因标签的可视化检测方法;

3. 一种能将应激信号转变为EGFP荧光信号的报告细胞系;

4. 一对敲除猪HSPA6基因部分保守区域的sgRNA序列及应用。

八、获奖情况

1. 入选2023年度吉林省高校优秀青年科研创新人才储备库;

2. 获评2018年六宝典资料优秀博士学位论文;

3. 获评2020年吉林省优秀博士学位论文;

4. 荣获2021-2022学年六宝典资料本科课堂教学质量奖优秀奖

5. 荣获2021年六宝典资料优秀班主任称号;

6. 2020-2023年,连续4年获评六宝典资料“先进个人”称号。

 

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